In silico two-hybrid system for the selection of physically interacting protein pairs.

Discovering Domains Mediating Protein Interactions

Background: Protein-protein interactions do not provide any direct information re‌garding the domains within the proteins that mediate the interactions. The majority of proteins are multi domain proteins and the interaction between them is often defined by the pairs of their domains. Most of the former studies focus only on interacting do‌main pairs. However they do not consider the in...

In Silico Design and Verification of LAMP-BDNF Chimeric Protein for Presentation of BDNF on the Surface of Exosomes for Drug Delivery Through Blood-Brain Barrier

Background and purpose: The mature form of brain-derived neurotrophic factor (BDNF) binds to BDNF/NT-3 growth factors receptor (Trk-B). This binding leads to activation of Ras–MAPK pathway which is integrated with cell growth and proliferation. The BDNF deficiency is correlated with various diseases and affects aging and miscellaneous. In the present study we aimed to design a chimeric LAMP-BDN...

Multi-objective optimization of two hybrid power generation systems for optimum selection of SOFC reactants heat exchangers mid-temperatures

Increasing efficiency and decreasing cost are the main purposes in the design of the power generation systems. In this study two hybrid systems: solid oxide fuel cell (SOFC)-gas turbine (GT) and SOFC-GT-steam turbine (ST); are considered. Increasing the SOFC input temperature causes thermodynamics improvement in the hybrid system operation. For this purpose, using two set of SOFC reactants heat...

Gene-Based Marker to Differentiate Among B, A, and R Lines in Hybrid Production of Rapeseed Ogura System

Background: In plant breeding program to produce hybrid varieties, pair of male sterile and restorer fertility lines are required. Differentiation of lines possessing restorer fertility allele from the lines lacking it remove the need for the progeny test, and thus reducing the time and the cost in the hybrid production procedure. Canola breeding program in Iran has concentrate...

A hybrid decision making system using DEA and fuzzy models for supplier selection in the presence of multiple decision makers